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Commonly used sterilization methods

The commonly used methods of sterilization are: dry-heat sterilization, moist heat sterilization, radiation sterilization, UV sterilization, ethylene oxide sterilization and ozone sterilization. Moist heat sterilization is a process that uses moist heat as the lethal agent to render liquid and porous as well as hard goods items tree of viable microorganisms. There are two main types of processes used in moist heat sterilization: saturated steam sterilization and air over pressure sterilization.saturated steam sterilization is used primarily for porous and hard good loads, while air over pressure is used for liquid loads. Air over-pressure applications are used to minimize destruction or distortion of plastic containers or syringes containing liquids.
The sterilizers are used to sterilize many types of items, including porous or hard goods, for example, tools, laboratory glassware, product components, packaging as well as devices. Product components that are not part of a porous or liquid load, such as vials and syringes. The hospital has plenty of demand for vials and syringes. Disinfects the supply office is the hospital important key position, in medical service, holds the post of the aseptic goods the supply and is antiseptic. Cleaning materials and product intermediates. Product in final container ( terminal sterilization). Heat labile media. Culture media used in cell cultures and other process all need moisture heat or sterilized by filtration before use. Biological solutions and products, equipment as well as tools.

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The life cycle of sterilizer approach to validation activities should include a change control program and a quality risk management program. The quality risk management can be useful to identify and prioritize areas for improvement. For the technical staff who perform verification and validation activities, they shall be made aware of defects and errors that may be encountered as part of their job functions. A change control program would encompass the requirements for documenting and verifying all changes made to the sterilizer that would affect its validation state. And the quality risk management program would provide the end-user with the tools required to make intelligent risk-based decisions with respect to the design of the sterilizer, the sterilization process itself as well as the operation of the sterilizer. That is to say that the quality risk management can provide a proactive approach to identifying and controlling potential risks to quality throughout the product life cycle. The quality risk management may be used during qualification and validation to prioritize and develop test requirements and acceptance criteria, and may also be used in conjunction with change control program to determine the appropriate re-affirmation interval for the sterilizer. Ensure that planed and unplanned validation, re-validation and calibration activities are timely carried out and documented.

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